Group Members
Prof. Marcelo Ganzarolli de Oliveira
Principal Investigator
University of Campinas (M.S.), University of Campinas (Ph.D.), University of Southampton (Post-doc)
Prof. Marcelo Ganzarolli de Oliveira received his Ph.D. in Science from the University of Campinas (UNICAMP) in São Paulo state, Brazil, in 1992, where he was appointed Assistant Professor in 1987. After his doctoral studies he served as Visiting Research Fellow at the Chemistry Department of the University of Southampton, UK, from 1993 to 1995.
He was appointed Associate Professor (2000) and Full Professor (2014) in the Physical Chemistry Department of the Institute of Chemistry of UNICAMP, where he currently develops his studies aimed at the preparation of polymeric biomaterials for the controlled release of nitric oxide (NO).
Current Members
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Post-docs
Rayane da S. Vale
Federal University of São Carlos, 2020 (Ph.D.)
Her project is focused on developing fully absorbable, nitric oxide-releasing intracoronary stents. These stents are made from polynitrosated polyesters, specifically poly(lactic acid), poly(caprolactone), or their blends. By employing techniques such as 3D printing and electrospinning, she aims to create stents that not only fully bioabsorb but also release nitric oxide locally, providing potential antithrombotic and pro-endothelial effects.
FAPESP Fellowship (2024).
Eronildo A. P. Junior
University of Campinas, 2023 (Ph.D.)
His project aims to develop new polymeric biomaterials, based on methacrylated hyaluronic acid and thiolated gelatin, for cardiovascular regenerative medicine, with the goal of treating coronary artery occlusion or stenosis through the 3D printing of innovative photo-reactive hydrogels that promote the controlled release of nitric oxide.
FAPESP Scholarship (2024)
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Ph.D. candidates
Herllan V. de Almeida
University of Campinas, 2022 (M.Sc. in Inorganic Chemistry)
His project aims to synthesize new organic-inorganic hybrid resins for 3D printing of NO-releasing blood contact devices. We will create polysilsesquioxanes and poly(2-hydroxyethyl methacrylate) based devices using Digital Light Processing (DLP) 3D printing technology.
CNPq Scholarship (2022)
Mateus P. Bomediano
University of Campinas, 2021 (B.S. in Chemistry)
His project is focused on the development of 3D printed vascular prostheses based on nitric oxide-releasing hydrogels. Hydrogels functionalized with photocrosslinkable groups will be coated with polydopamine improving the biocompatibility of the constructs for biomedical applications.
FAPESP Scholarship (2022)
Elizaura H. C. Silva
Federal University of Maranhão, 2020 (M.Sc. in Analitical Chemistry)
Her project is focused on developing perfusable nitric oxide-releasing 3D printed vascular prostheses. Photocurable polymeric resins will be synthesized and two distinct 3D printing techniques, digital light processing and needle extrusion, will be used to fabricate biocompatible constructs that might be useful for the treatment of several cardiovascular diseases.
CNPq Scholarship (2021)
Past Members
Laura C. E. da Silva
University of Campinas, 2014 (M.Sc.)
University of Campinas & Lund University (internship), 2018
Her projetct involves the preparation of multilayered hybrid nanoparticles made up of poly(hydroxyethyl methacrylate) and polysilsesquioxane for the localized co-delivery of nitric oxide (NO) and antitumoral drugs. Self-organized and multicomponent hydrogels fot the topical NO release will also be produced with this polymeric system. This project is being developed under collaboration with Prof. Alexander Zelikin from Aarhus University - Denmark.
FAPESP Fellowship (2019)
Daniele M. Catori
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State University of Maringá (M.Sc.)
Her project concerns the development of injectable gels that are able to locally deliver nitric oxide for the regeneration of cartilaginous tissue. Absorbable hydrogels made up of hyaluronic acid and non-absorbable hydrogels made up of poly(vinyl acetate) will be prepared by in situ photopolymerization as well as 3D printing.
CAPES Scholarship (2019)
Marcos V. Lorevice
Federal University of São Carlos, 2015 (M.Sc.)
Federal University of São Carlos & Paris Diderot University (internship), 2019
His project involves the development of chemically modified polysaccharides (pectin and chitosan) containing bivalent ions and/or methacrylate groups as well as nitric oxide-releasing end-groups for preparing novel biocompatible and 3D printable hydrogels resins that result in nitric-oxide releasing devices with tailored mechanical properties that are suitable for wound healing applications.
FAPESP Fellowship (2021)
Matheus F. de Oliveira
Federal Fluminense University (B.S.)
His project aims to the development of fully absorbable and nitric oxide (NO) releasing intracoronary polyester stents. It involves the investigation, synthesis, casting, and evaluation of polynitrosed polyester NO donors, pure and in blends, to try and provide the stent with a complete bioabsorption property and with localized release of NO, which in turn displays antiplatelet, anti-restenotic and pro-endothelial actions.
FAPESP Scholarship (2017)
Murilo I. Santos
University of Campinas (M.S.)
His project involveed the development of photocrosslinkable hydrogels based on poly(ethylene oxide)-poly(propylene oxde)-poly(ethylene oxide) triblock copolymers (Pluronics®) for Digital Light Processing (DLP) 3D printing. The printed hydrogels were loaded with NO donors and their biological action will be investigated.
Co-supervision with Prof. Maria do Carmo Gonçalves – Institute of Chemistry (Unicamp) - (08/2018 - 03/2020)
CAPES Scholarship
Guilherme Fadel Picheth - 2017 - 2018
His project involved the synthesis of Pluronic F127 triblock polymers containing end-group modifications to release nitric oxide. The project´s goal was to preserve the polymer’s thermo-sensitivity and simultaneously provide activable NO-releasing moieties for wound healing applications.
Mathilde Champeau - 2015 -2016
Her project was devoted to the synthesis of poly(acrylic acid)/PEO-PPO-PEO hydrogels charged with a nitric oxide donor. The hydrogels were molded as membranes and used in topical applications for improving wound healing. The project involved a collaborative work with the Faculty of Medical Sciences at University of Campinas, UNICAMP.
Patricia Taladriz-Blanco – 09/2013-04/2015
Chiara Montemurro – 04/2013-01/2015
Rafael Vercelino – 04/2010-01/2013
Kamila Cristina Silva – 11/2011-11/2012
Amedea Barozzi Seabra – 11/2005-07/2008 and 04/2010-03/2011
Regiane da Silva Gonzales – 08/2008-07/2009
Rodrigo Silveira Vieira – 06/2008-03/2009
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Doctorate (Ph.D)
Scheila Alves - 03/2014 - 2017
Victor Baldin – 03/2011-06/2016
Marília Meira Dias – 03/2007-02/2012
Co-supervision with Prof. José Barreto Campello Carvalheira – Faculty of Medical Sciences (Unicamp)
Gabriela Freitas Pereira de Souza – 02/2008-07/2011
Maíra Martins de Souza Godoy Simões – 08/2006-06/2011
Rogério Côrte Sassonia – 07/2004-10/2009
Regiane da Silva Gonzalez – 03/2005-07/2008
Fernanda Ibanes Simplício – 03/2003-03/04/2007
Amedea Barozzi Seabra – 03/2003-01/2006
Silvia Mika Shishido – 03/1998-16/04/2003
Marlus Pinheiro Rolemberg – 09/2000-07/2002
Co-supervision with Prof. Maria Alvina Krähenbühl – Faculty of Chemical Engineering (Unicamp)
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Master (M.S.)
Yuliana Pérez Sánchez - 03/2017 - 02/2019
Alexandre Dias Barbosa - 08/2016 - 08/2018
Flávia Mesquita Cabrini - 08/2016 - 05/2018
Thatiane Cristine Camargo Marini – 01/2014-10/2016
Marcelo F. de Azevedo Silva – 08/2012-09/2016
Vicente Gomes de Oliveira – 08/2014-09/2016
Sarah De Marchi Lourenço – 07/2013-04/2015
Fernanda Seabra Schanuel – 03/2012-02/2015
Co-supervision with Prof. Andréa Monte Alto Costa – Rio de Janeiro State University (UERJ)
Ana Beatriz Manzano Nascimento – 08/2012-11/2014
Co-supervision with Prof. Dra. Carolina Vautier Teixeira Giongo – Federal University of São Paulo (Unifesp)
Raphael Henrique Marques Marcilli – 08/2012-10/2013
Maíra Martins de Souza Godoy Simões – 11/2004-06/2006
Alessandro Correa Prudente dos Santos – 03/2008-03/2010
Co-supervision with Prof. Cássio Luís Zanettini Riccetto – Faculty of Medical Sciences – Unicamp
Regiane da Silva Gonzalez – 03/2004-01/2005
Lais Calixto Santos – 08/2001-09/2003
Amedea Barozzi Seabra – 03/1999-02/2001
Silvia Mika Shishido – 03/1996-06/1998
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Research Trainees
Giovana Bosso Romano
University of Campinas (B.S.) - current
Giovana is working on the light-assisted 3D printing of organic-inorganic hybrid hydrogels in which S-nitrosoglutathione (GSNO), an endogenous NO-donor, is incorporated after printing to promote NO-relasing properties useful for several biomedical applications.
FAPESP Scholarship (2021)
Yasmim R. Lopes
University of Campinas (B.S.) - current
Yasmin worked on the coating of intracoronary stents and catheters with photopolymerizable methacrylated poly(dodecanediol citrate) and nitric oxide donors to improve blood compatiblility. This project was under collaboration with Prof. Melissa Reynolds, Colorado State University - United States of America.
FAPESP Scholarship (2018)
Giovanna J.V.P dos Santos
University of Campinas (B.S.) - current
Giovanna was related to the development of bioabsorbable and biocompatible membranes anchored with naturally occurring nitric oxide donors in the human body. These membranes are being employed to accelerate the reepithelialization rate of skin wounds. This project was under collaboration with Prof. Cécile Dreiss, King´s College London - United Kingdom.
FAPESP Scholarship (2016)
Marina F. Maximo
University of Campinas (B.S.) - current
Marina was based on the development of polu(N-isopropyl acrilamide) (PNIPAAM) membranes containing anchored nitric oxide donors. These membranes are being employed to the prolonged NO delivery in skin wounds.
Leonardo Pinheiro Giglio - 08/2016 - 08/2018
Lucas Militão - 11/2015 - 10/2016
Amanda Carrico – 02/2016-08/2016
Karen Slis Raggio Santos – 07/2013-12/2014
Adriana Pereira Lopes Limeira – 02/2012-07/2013
Murilo Metzger Denny – 01/2014-12/2014
Caroline Simões Pereira – 06/2011 a 05/2012
Letícia Marques da Silva – 12/2012-08/2013
Elisa Silva Ferreira – 01/2010-07/2012
Arthur Teixeira Melo – 08/2011-11/2012
Amanda Osteno Lino – 05/2011-09/2012
Natália Vance – 01/2011-06/2011
Cybele Ribeiro Moura – 12/209 a 12/2010
Bruno Morandi Pires – 04/2009-07/2011
Marcela Gennari – 10/2007-09/2008
Flaviane Alves dos Santos – 03/2009-12/2009
Joseph Elias – 07/2008-08/2008
Jaqueline Priscilla Denadai – 05/2007-11/2008
Gabriela Freitas Pereira de Souza – 04/2004-03/2007
Thiago Costa Ferreira Gomes – 01/2005-12/2005
Juliana Correia Bergallo Vaz – 09/1999-09/2000 and 03/2001-03/2002
Co-supervision with Prof. Rahoma Sadeg Mohamed – Faculty of Chemical Engineering – Unicamp
Amarildo Grando – 05/1999-12/2000
Dirnei Aparecido Machado – 02/1995-03/1996
Fabiana Ocampos – 09/1995-10/1996
Ricardo Ganães Cosso – 06/1991-11/1991
Euler Martins Lage – 06/1990-04/1991